Clinical analysis of L-amlodipine in the treatment of mild hypertension

Objective To observe the clinical effect of L-amlodipine in the treatment of mild hypertension. Methods One hundred and eight patients with mild hypertension were randomly divided into study group and the control group, with 54 patients in each group. The study group was given 2.5 mg of L-amlodipine, once a day. The control group was given 5 mg of amlodipine, once a day. All patients adjust the dose according to blood pressure. The efficacy, blood pressure, heart rate, carotid intima-media thickness (IMT) and adverse reactions were compared be- tween the two groups. Results The total effective rate was 94.4% in the study group and 92.6% in the control group, with no statistically significant different between the two groups (P0.05). The blood pressure of the two groups were decreased 3, 6 and 12 months after treatment (P0.05). The diastolic pressure of the study group was significantly lower than that of the control group 3 months after treatment. The heart rate of the study group was not significantly changed after treatment, while that of the control group was significantly increased 6 and 12 months after treatment. Carotid IMT of the study group was significantly decreased, showing statistically significant difference with that of the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion The clinical effect of L-amlodipine in mild hypertension is satisfactory. It can reduce the risk of cardiovascular disease, with low dose and less adverse reactions, which is worthy of clinical popularization.