2006•Tianjin yiyaoRequires access

The Expression of Survivin in Laryngeal Carcinoma and the Relationship between Survivin and Apoptosis

Ruili Zhao

Abstract

Objective: To investigate the effect of survivin gene in the development of laryngeal carcinoma. Methods: Survivin mRNA ,protein and apoptosis in laryngeal carcinoma tissue cells of forty-two patients were detected by RT-PCR and FCM. Results: Survivin mRNA and protein were both highly expressed in laryngeal carcinoma tissue cells especially in Ⅲ and Ⅳ phases. The apoptosis rate decreased in the survivin expression group and there was a negative correlation between survivin protein(FI) and laryngeal carcinoma cell apoptosis rate. Conclusion: Survivin gene may take part in the genesis and the growth of laryngeal carcinoma through inhibiting cell apoptosis, what is more, it indicates more invasive laryngeal carcinoma and poor prognosis.

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Key concepts: Survivin, Apoptosis, Carcinoma, Inhibitor of apoptosis, Cancer research, Laryngeal Neoplasm, Messenger RNA, Gene