Study on Preparation of Molecularly Imprinted Polymer Microspheres by Precipitation Polymerization with 1-Phenyl-1-propanol as Template

Molecularly imprinted polymer microspheres were prepared by precipitation polymerization.Methacrylic acid was used as functional monomer and 1-phenyl-1-propanol was used as template.The effects of reaction conditions were studied,including the kind of solvent,polymerization temperature,the concentration of template and initiator,rotational speed and pre-polymerization time.The appropriate polymerization conditions were at 60℃,with acetonitrile as solvent and at the concentrations of both template and initiator of 0.01 mol/L.The obtained molecularly imprinted polymer microspheres showed good specific recognition and higher affinity capacity in the rebinding experiments.