Preparation of MIP Microspheres by Precipitation Polymerization with 1-Phenyl-1-Propanol as Template

Molecular imprinting polymer microspheres were prepared by precipitation polymerization with methacrylic acid as functional monomer and 1-phenyl-1-propanol as template. The effects of synthesis conditions, including the kind of solvent, polymerization temperature, the concentration of template and initiator, rotational speed and pre-polymerization time, on the characteristics of the molecularly imprinted polymer microspheres were studied. The rebinding experiments showed that the molecularly imprinted polymer microspheres synthesized by precipitation polymerization at 60°C, with acetonitrile as solvent and the concentrations of both template and initiator of 0.01mol L-1, have good specific recognition and higher affinity capacity.