Expression levels of P-glycoprotein and lung resistance protein in ovarian cancer tissues and their clinical significance

Objective:To explore the expression levels of P-glycoprotein(P-gp) and lung resistance protein(LRP) in primary epithelial ovarian cancer(POEC) tissues and their relation to chemotherapy.Methods:The expression levels of P-gp and LRP in paraffinaceous ovarian samples from 56 cases with POEC,15 cases with benign ovarian tumors and 12 cases with normal ovarian tissues were detected by immunohistochemical staining,and the pathologic data of 56 cases with POEC were analyzed.Results:①The positive expression rates of P-gp and LRP in cases with POEC were higher than those with benign ovarian tumors and normal ovarian tissues.②There was no correlation between the expression levels of P-gp and LRP and age,histological types and clinical stagings,but there was a correlation between LRP expression and ascites.③The positive expression rates of P-gp and LRP in cases undergoing primary chemotherapy were higher than those without primary chemotherapy(P0.01).④Those with positive expression rates of P-gp and LRP had poor effect on chemotherapy.Conclusion:①The expression rates of LRP and P-gp in cases with POEC are higher than those with normal ovarian tissues.②Chemotherapy can improve the positive expression rates of LRP and P-gp in cases with POEC.③The expression rates of LRP and P-gp may predict the short term efficacy of combination chemotherapy on POEC.