The expression and clinical significance of p-gp,GST-π and LRP in ovarian cancer

Objective To study the expression of P-glycoprotein(p-gp),glutathione S-transferase-π(GST-π)and Lung resistant-related protein(LRP)in epithelial ovarian cancer;in addition,assess their predictive value as indicators of resistance to chemotherapy.Methods The expression of p-gp、GST-π and LRP in paraffin sections of 70 cases of epithelial ovarian cancer was studied using immunohistochemical staining.Results(1)The positive expression of p-gp,GST-π and LRP in epithelial ovarian cancer was 31.4%(22/70)、65.7%(46/70)、58.6(41/70),respectively.The difference between them and their expressions in normal ovaries and ovarian benign tumor was statistically significant(P0.05).(2)The expession of p-gp、GST-π and LRP was not associated with clinical stage and histologic type.(3)For 42 postoperative residual ovarian cancer patients,the response rate to chemotherapy of the p-gp positive group and negative group was 40% and 66.7%,the difference being not statistically significant.(P0.05).The response rate to chemotherapy of the GST-π positive group and negative group was 42.3% and 81.3%,the difference being statistically significant,(P0.05).The response rate to chemotherapy of the LRP positive group and negative group was 40% and 82.4%,the difference being statistically significant(P0.05).(4)p-gp、GST-π and LRP may express in one case.Conclusion The patients with GST-π and LRP postively stained show unsatisfied result to chemotherapy,and detection of CST-π and LRP is useful in assessing resistance to chemotherapy.