Expression and Clinical Significance of Multidrug Resistance Related Protein in Epithelial Ovarian Carcinomar

Objective To explore the expression and the effect of multidrug resistance related protein on chemo-therapy for the treatment of epithelial ovarian carcinomar.Methods Immunohistochemistry SP method was used to detect the expression of multidrug resistance related protein in 36 cases with epithelial ovarian carcinoma,10 cases with borderline tumor and 10 cases with benign tumor.Results The positive rates of P-gp、GST-πand LRP increased significantly from benign to borderline,and from borderline to malignant epithelial ovarian tumor.The positive rates of P-gp、GST-πand LRP increased significantly from benign or borderline to malignant epithelial ovarian tumor(P0.001).There was no relationship between the expression of P-gp、GST-πand LRP in benign and borderline tepithelial ovarian tumor(P0.05).In the cases with FIGO staging I and II,and histological grade I or II,the positive rates of P-gp and LRP were significantly lower than those in cases with FIGO staging III and IV,and histoligical grade III,respectively (P0.001),but there was no relationship between the expression of GST-π in grade I or II and grade III (P0.05).The positive rates of P-gp、GST-πand LRP expression was nagative correlated with the efficiently of chemo-therapy(P0.05).Conclusion The detection of P-gp、GST-π、LRP and their gene products in combination may be useful in selecting anticancer-drug and providing prognostic information in malignant epithelial ovarian tumor.