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2004•Journal of Hubei Vocational-Technical CollegeRequires access

Using SCEG Technique to Measure the Effect of DNA Damage by Fluuoride in Human Embryo Hepatocytes

Chu Qi-long

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Abstract

Objective; To explore the effects of DNA damage in duced by fluoride in human embryo hepatocytes . Methods: The DNA damage was measured after human embryo hepatocytes were incubated with 40μg/ml, 80 g/m, and 160 g/ml sodium fluoride by using Single Cell Electrophosis (SCGE) respectively. Results: The DNA damage rate of human embryo hepatocytes in the fluoride group was significantly higher than that in the control group, with the Ridit value were 0.5815, 0. 8145 , and 0. 8923 respectively. Moreover, the rate of DNA damage in high fluoride group was significantly higher than that in the low fluoride group. Conclusion: Fluoride exposure can cause DNA damage of human embryo hepatocytes, and there exists a good dose -effect relationship.

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What this paper is about

Objective; To explore the effects of DNA damage in duced by fluoride in human embryo hepatocytes . Methods: The DNA damage was measured after human embryo hepatocytes were incubated with 40μg/ml, 80 g/m, and 160 g/ml sodium fluoride by using Single Cell Electrophosis (SCGE) respectively. Results: The DNA damage rate of human embryo hepatocytes in the fluoride group was significantly higher than that in the control group, with the Ridit value were 0.5815, 0. 8145 , and 0. 8923 respectively. Moreover, the rate of DNA damage in high fluoride group was significantly higher than that in the low fluoride group. Conclusion: Fluoride exposure can cause DNA damage of human embryo hepatocytes, and there exists a good dose -effect relationship.

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Available abstract

Objective; To explore the effects of DNA damage in duced by fluoride in human embryo hepatocytes . Methods: The DNA damage was measured after human embryo hepatocytes were incubated with 40μg/ml, 80 g/m, and 160 g/ml sodium fluoride by using Single Cell Electrophosis (SCGE) respectively. Results: The DNA damage rate of human embryo hepatocytes in the fluoride group was significantly higher than that in the control group, with the Ridit value were 0.5815, 0. 8145 , and 0. 8923 respectively. Moreover, the rate of DNA damage in high fluoride group was significantly higher than that in the low fluoride group. Conclusion: Fluoride exposure can cause DNA damage of human embryo hepatocytes, and there exists a good dose -effect relationship.

Key concepts: Embryo, DNA damage, Fluoride, DNA, Sodium fluoride, Chemistry, Molecular biology, Hepatocyte

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Using SCEG Technique to Measure the Effect of DNA Damage by Fluuoride in Human Embryo Hepatocytes — Research Paper | ScholarLens