Effects of rosuvastatin on expression of periostin protein in rats with acute myocardial infarction

Objective To evaluate the effects of rosuvastatin on expression of periostin (Pn)protein in rats with acute myocardial infarction and to investigate the improvement of myocardial reconstruction mechanism. Methods Female adult SD rats were randomly divided into sham group, model group and benazepril group (18in each group). Thirty-six female SD rats with ligated LAD were used to establish models of acute myocardial infarction (AMI), twenty four hours later, the models were randomly divided into acute myocardial infarction (AMI) as control group and rosuvastatin intervention (ROS) group.Another 18 rats were tested with pierced but not ligated LAD as sham-operated group (Sham). Rats in ROS group were given rosuvastatin by gavage at 6 mg/(kg·d) dose levels to soluble in 1 ml clear water, whereas rats in the other two groups were given 1 ml clear water each day. Four weeks later, compare the differences of collagen volume fraction (CVF), periostin protein, TGF-β1 mRNA and periostin mRNA. Results Myocardial CVF, periostin protein, TGF-β1 mRNA and periostin mRNA were reduced in the ROS group compared with rats in the AMI group (P0.05), both ROS group and AMI group were significantly higher than those in the Sham group (P0.05). Conclusion Rosuvastatin can reduce the expression of periostin in the damaged myocardial, may be one of the mechanism of myocardial remodeling improvement.