2014•Zhongguo xunhuan zazhiRequires access
Effects of Rosuvastatin on Production of Reactive Oxygen Species and Expressions of Periostin, Cardiotrophin-1 in Experimental Rats After Acute Myocardial Infarction
Li E
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Abstract
Objective: To investigate the effects of rosuvastatin on reactive oxygen species(ROS) production and periostin, cardiotrophin-1(CT-1) expression, and to explore rosuvastatin on ventricular remodeling in experimental rats after acute myocardial infarction(AMI).Methods: A total of 45 male Wistar rats were randomly divided into 2 group, Sham operation group, n=15 and AMI group, n=30, the AMI model was established by left anterior descending coronary ligation. After 24 hours of AMI, the rats were further divided into 2 groups, AMI + rosuvastatin group, the rats received gastric rosuvastatin 1mg/(kg·d), and AMI group, the rats received gastric normal saline. n=15 in each group and all animals were treated for 6 weeks. The mRNA and protein expressions of CT-1 and periostin were examined by real time RT-PCR and immunohistochemistry, the contents of superoxide anion(O2-·) and hydroxy radical(OH·) were detected by colorimetric method among different groups. Results: Compared with Sham operation group and AMI + suvastatin group, the mRNA and protein expressions of CT-1, periostin, the contents of(O2-·),(OH·) and left heart weight index were increased in AMI group at non-infraction zone, P005. Compared with Sham operation group, the mRNA and protein expressions of CT-1, periostin, the contents of(O2-·),(OH·) and left heart weight index were increased in AMI + suvastatin group at non-infraction zone, P005. Compared with AMI group, the mRNA and protein expressions of CT-1 and periostin were decreased in AMI + rosuvastatin group, P005.Conclusion: Rosuvastatin may improve ventricular remodeling via inhibiting ROS production and CT-1, periostin expression in experimental rats after AMI.