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2008•Journal of OncologyRequires access

Radiosensitization of Celecoxib for Glioma Cells

Xiao-Ting Xu

Open publisher page 1 citations

Abstract

Purpose To study the radiosensitization of celecoxib to three strains of glioma cells. Methods Celecoxib with proper concentration was adapted for radiosensitive experiments for SHG-44 cells,767 cells and C6 cells. The cells were randomized into two groups,radiation alone group (R),and radiation combined with celecoxib group (R+D). Celecoxib’s radiosensitization was measured by clongenic assay,and survival curve was described. Result Celecoxib displayed radiosensitizing effect in the three strains of glioma cells. The Value of D0,Dq,SF2 and D0.01 of group R+D was significantly lower than that of group R (tSF2=83.5,P=0.014;tD0.01=9.28,P=0.011;tD0=3.985,P=0.058;tDq=3.348,P=0.075). Conclusion The COX-2 selected inhibitor,celecoxib could enhance radiation effect in three strains of glioma cells in vitro. Celecoxib might become an effected radiosensitizer in the treatment for glioma.

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What this paper is about

Purpose To study the radiosensitization of celecoxib to three strains of glioma cells. Methods Celecoxib with proper concentration was adapted for radiosensitive experiments for SHG-44 cells,767 cells and C6 cells. The cells were randomized into two groups,radiation alone group (R),and radiation combined with celecoxib group (R+D). Celecoxib’s radiosensitization was measured by clongenic assay,and survival curve was described. Result Celecoxib displayed radiosensitizing effect in the three strains of glioma cells. The Value of D0,Dq,SF2 and D0.01 of group R+D was significantly lower than that of group R (tSF2=83.5,P=0.014;tD0.01=9.28,P=0.011;tD0=3.985,P=0.058;tDq=3.348,P=0.075). Conclusion The COX-2 selected inhibitor,celecoxib could enhance radiation effect in three strains of glioma cells in vitro. Celecoxib might become an effected radiosensitizer in the treatment for glioma.

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Available abstract

Purpose To study the radiosensitization of celecoxib to three strains of glioma cells. Methods Celecoxib with proper concentration was adapted for radiosensitive experiments for SHG-44 cells,767 cells and C6 cells. The cells were randomized into two groups,radiation alone group (R),and radiation combined with celecoxib group (R+D). Celecoxib’s radiosensitization was measured by clongenic assay,and survival curve was described. Result Celecoxib displayed radiosensitizing effect in the three strains of glioma cells. The Value of D0,Dq,SF2 and D0.01 of group R+D was significantly lower than that of group R (tSF2=83.5,P=0.014;tD0.01=9.28,P=0.011;tD0=3.985,P=0.058;tDq=3.348,P=0.075). Conclusion The COX-2 selected inhibitor,celecoxib could enhance radiation effect in three strains of glioma cells in vitro. Celecoxib might become an effected radiosensitizer in the treatment for glioma.

Key concepts: Celecoxib, Radiosensitizer, Medicine, Glioma, In vitro, Pharmacology, Cancer research, Radiation therapy

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