Application of clopidogrel combined with atorvastatin calcium in the prevention of cerebral infarction after TIA

Objective To observe the effect of clopidogrel combined with atorvastatin calcium in the prevention of cerebral infarction after transient ischemic attack( TIA). Methods 60 patients with TIA were randomly divided into two groups. Patients in control group( n = 30) were given clopidogrel 50 mg once daily after onset. Patients in observation group( n = 30) were added atorvastatin calcium 20 mg once daily. All the patients were followed up for one year,The four indexes of blood lipid was detected using automatic biochemical analyzer before treatment and at the end of the follow-up,and the prothrombin time( PT),activated partial thromboplastin original time( APTT) and the PLT( platelet) count were recorded. The carotid artery plaque of all the patients was examined by color Doppler ultrasonography,and the quantity and quality of plaque was observed. The incidence of cerebral infarction,cerebral hemorrhage and other adverse events were recorded during the follow-up period. Results After treatment,TC,TG,LDL-C of the observation group decreased( P 0. 05),there were significant differences between the two groups( P 0. 05). No significant difference was found in PT,APTT,PLT between the two groups( P 0. 05). The incidence of carotid plaque and the mean average keyed block plaque of observation group were significantly lower than those of control group( P 0. 05),there was no significant difference in the average echogenic plaques between the two groups( P 0. 05). There were 1 case(3. 33%) and 6 cases(20. 00%) of cerebral infarction or cerebral hemorrhage in observation group and control group,there were significant differences between the two groups( P 0. 05). No bleeding was observed at the site of skin and mucous membranes and viscera,etc. Conclusion Clopidogrel combined with atorvastatin calcium in patients with TIA,can significantly reduce the incidence of cerebral infarction by regulating lipid and antiplatelet therapy,and the effect is better than clopidogrel alone.