Study on the expression and correlation of CD44v6 and uPA in gastric cancer

Objective:To study the expression of urokinase-type plasminogen activator(uPA) and cluster of differentiation 44-6 on the infiltration and metastasis of gastric cancer and to investigate the relationship of their expression. Methods:Immunohistochemical technique (S-P method) was applied to detect CD44v6 and uPA in 67 cases of gastric cancer. Results:(1)Of the 67 cases gastric cancer, 34(50.75 %) were positive for CD44v6 , 35 (52.24%) for uPA. The co-expression of CD44v6 and uPA was 26(38.81%);(2)The CD44v6 positive rate in well differentiated carcinoma was higher than that in poorly one (P0.05) ; The same result was concluded about uPA(P0.01);(3)CD44v6 and uPA positive rates in the cases with lymph node metastasis were relatively higher than that without lymph node metastasis(P0.01);(4)The differences of CD44v6 and uPA positive rates were significant among cases of early gastric cancer and cases with muscularis involvement and cases with whole layer infiltration(P0.01);(5)The relationship was significant between the expression of CD44v6 and uPA in gastric cancer (P0.01) . Conclusion:The study shows that CD44v6 and uPA may play an important role in histologic types or invasion or metastasis of gastric cancer. The assay of CD44v6 and uPA in patients with gastric cancer , as the clinical valuable marker, has the active role and instructive significance in estimating prognosis and working out rational therapy.