Relationship between uPA and NF-κB p65 expression and its clinical significance in breast cancer

AIM: To evaluate the relationship between uPA and NF-κB p65 expression and its clinical significance in breast cancer. METHODS: The uPA mRNA was measured by real-time fluorescent quantitative PCR in 46 cases of breast cancer tissues and their adjacent counterparts. NF-κB p65 were measured using immunohistochemistry. RESULTS: The expression of uPA gene was elevated in 63% of cases, and there was a strong correlation between NF-κB p65 and uPA expression (r=0.451,P0.01). In addition, the expression of uPA was associated with numbers of axillary lymph node involvement and tumor size. However, no significance was found in uPA expression in the age, pathological type and distant metastasis organ classification. CONCLUSION: The uPA gene is highly expressed in most of the breast cancer, and there is strong correlation to NF-κB p65 expression, number of lymph nodes involvement and tumor size.