Association between AT1R gene A1166C polymorphism and essential hypertension of Xinjiang Uygur nationality

Objective To investigate the association between angiotensinⅡtype 1receptor(AT1R)gene A1166C polymorphism and essential hypertension(EH)in Uygur nationality and to clarify the action mechanism of AT1R gene A1166Cin the occurrence of EH.Methods 636cases of Uyghur population blood samples including 167cases of EH group and 469cases of control group were collected.Then polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was adopted to examine the AT1Rgene A1166Cpolymorphism.The distribution of AA,AC and CC genotypes and the different frequencies of the points A,C in EH and control groups were analyzed.Results The AC+CC genotype and C allele frequency in EH group were significantly higher than those in control group,the difference was statistically significant(χ2=10.179,P=0.001);the risk of EH of the people with AC+CC genotypes was 1.6(OR=1.612,95%CL:1.191-2.183)times than that of the people with AA genotype.Conclusion There might be some relationship between AT1R gene A1166C polymorphism and the EH in Uighur population.