Relationship between angiotensin II type 1 receptor gene A1166C polymorphismand essential hypertension in Yi population in Yunnan province

Objective:To investigate the relationship between angiotensin Ⅱ type 1 receptor(AT1R) gene A1166C polymorphism and essential hypertension(EH) in Yi population in Yunnan province.Method:Two hundred and thirty-five EH patients(EH group) and 180 normal controls(normal group) of Yi population in Yunnan province were recruited.The AT1R A1166C polymorphism was determined by PCR-RFLP technique.Then the possible association between the gene polymorphism and EH was analyzed.Result:Frequencies of the AA and AC+CC genotypes were 91.9%,8.1% in EH group,and 95.6%,4.4% in normal group,respectively.Derived allele frequencies of the A1166 were 95.7% in EH group and 97.8% in normal group.There was no significant difference in A1166C genotypes distribution and allele frequencies between the two groups.But for female,frequencies of AC+CC genotype and 1166C allele in EH group were higher than those in normal group(P0.05).Conclusion:The AT1R A1166C polymorphism may be involved in the pathogenesis of EH in female of Yi population.