Association of AngiotensinIIType 1 Receptor gene A1166C polymorphism with Essential Hypertension in Xinjiang Uygur population

Objective:The rennin-angiotensin system(RAS)is implicated in the pathogenesis of hypertension AngiotensionⅡ(AngⅡ)is the biologically active peptide of the RAS and the effects of AngⅡare mainly mediated by the angiotensinⅡtype 1 receptor(AT1R).To investigate the correlation between AT1R gene Al166C polymorphism with essential hypertension in Xinjiang Uygur population,and investigate the distribution of genotype and allele frequencies of AT1R gene. Methods:One hundred and twenty-six patients with essential hypertension and one hundred forty-three normal blood pressure controls were included in the study to assess the contribution of polymorphism of AT1R.Then the polymerase chain reaction- restriction fragment length polymorphism(PCR-RFLP)method was used for the detection AT1R genotype.Results:The genotypes of the variants were found to be in Hardy-Weinberg equilibrium in Uygur group,AA,AC frequencies of genotype were 73%、27%and 74.8%,25.2% in EH and NT groups respectively.C allele frequencies were 13.5% and12.6% respectively. Significant difference were not seen between EH and NT groups.(p＞0.05).Conclusions:Our results suggested that the AT1R gene A1166C polymorphism might be not associated with hypertension in Uygur population.