Immune Function Change of Patients with Paraquat Poisoning and Its Clinical Significance

[Objective]To explore the changes of 7 immunological items in patients with paraquat(PQ) poisoning,provide the reference for clinical prognosis and treatment.[Methods]The patients were divided into mild group,moderate group and severe group according to the misusage dose of parquet.7 immunological items of venous blood were tested at the 2nd and 8th day after poisoning,which included interleukin-2(IL-2),tumor necrosis factor(TNF),IgG,IgA,IgM,C3 and C4.38 patients and 30 healthy controls were observed.[Results]At the 8th day,TNF level of mild group was significantly lower than that of control group,the levels of IL-2 of moderate group and severe group were significantly lower than that of control group(P0.01),TNF levels of moderate group and severe group were lower than that of control group,but there was no statistical significance.The IgA levels of moderate group and severe group increased significantly(P0.05) at the 2th day after poisoning,the IgA levels of moderate group and severe group were significantly higher than that of control group(P0.05 and P0.01) at the 8th day.At the 2th and 8th day,the IgA levels of moderate group and severe group were significantly higher than that of mild group(P0.05).[Conclusion]Many immunological items changed in patients with parquet poisoning.