The influence of thymic factor on severe thoracic trauma patient's serum IL-6,TNF-α levels

Objective To study the level changes of (IL-6) and (TNF-α) of patients with severe thoracic trauma in the treatment added with thymic factor. Methods All the cases were divided into thymic factor treatment group (group A,68 cases) and group B(without thymic factor,57 cases),and healthy persons were taken as control (group C,30 cases).With the methods of radioimmunoassay the serum IL-6,TNF-α levels in the A and B groups were measured on the 2nd 4th,7th day after hospitalization.In addition,the incidence rates of ARDS and infection rates of A and B groups were compared.Results The serum IL-6,TNF-α levels of group A and group B were higher on the 2nd day after hospitaiization than the group C(P0.01); the serum IL-6 and TNF-α levels of group A on the 4th day were significantly lower than that of on the 2nd day after hospitalization (P0.05), while it was lowest on the 7th (P0.05);the serum IL-6 and TNF-α levels of group B on the 4th day were significantly higher than that of on the 2nd day after hospitalization (P0.05), while it was lower on the 7th (P0.05), but on the 7th day there was not significantly difference than that of on the 2nd day. In the incidence rate of ARDS and infection rate there were significant differences between group A and group B (P0.05).Conclusion The levels of serum IL-6,TNF-α were significantly higher on severe thoracic trauma, were the highest on the 4th day. Thymic factor can effectively decrease the serum IL-6,TNF-α levels of severe thoracic trauma patients, and decrease the incidence rate of ARDS and infection rate.