Analysis on the change of HFMD caused by EV71 virus immune status of children

Objective To investigate the cause of EV71 HFMD child immunization status changes. Methods 120 cases with hand, foot and mouth disease were selected from June 2013 to December 2014 in our hospital, according to severity they were divided into the mild group(n=60), the severe group(n=60), 60 cases of children were collected came to our hospital for normal healthy physical examination as the same period as the mild group and the severe group and considered them as the control group. IL-10 level, humoral and cellular immune function of three groups were measured. Results Ig M, IL-10 levels of the mild group, severe group were higher than the control group, Ig G, Ig A, Ig M, IL-10 levels of the severe group was higher than mild group(P 0.05). CD16+ 56+, CD23+, CD19+ of Mild group, severe group was higher than the control group, CD25+ of the Mild group, severe group was lower than the control group(P 0.05), CD19+ of the severe group was higher than the mild group, CD16+56+,CD25+ was lower than the mild group(P 0.05); CD4+, CD8+ of the severe group was lower than the mild group and the control group(P 0.05). Conclusion Children with HFMD caused by EV71 virus exists cellular immunity, humoral immune dysfunction, the more severe the disease extent, cell-mediated immunity, humoral immune dysfunction more serious degree, should increase attention to timely detect and improve the prognosis of children and reduce mortality.