Changes of immunologic function in the patients with poisoning of paraquat and its clinical significance

Objective To intestvigate the changes of immunologic function in the patients with poisoning of paraquat(PQ ) and to explore clinical significance of these changes.Methods The markers of cell-mediated immunity(CD3 ,CD4 and CD8) and humoral immunity(IgG, IgA,IgM,C3 nd C4)were detected in second day and in eighth day 2 groups of patient (mild group,mordrate group and severe group),and these results were compared with normal control group.Results Comparison with normal control group,the levels of CD3 and CD4 were significant lower (P0.05, P0.01) and the levela of IgA (P0. 05)were significant higher than that in normal control group in second day after poisoning in the severe group .The levels of CD3 and CD4 in all patients were significant lower than that in control group (P0.05, P0.01), while the levels of IgA (P0.05) significant high in 8th day. The levels of CD3 and CD4 were significant higher in mild group than that in severe and mordrate group in second day and eighth day(P0.05,P0.01),and the level of IgA was significant higher than that in control group (P0.05).Conclusion The PQ poisoning may results in changes of immunologic function, with weakened the cell-mediated immunity and elevatede the humoral immunity.