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2010•China Modern MedicineRequires access

The expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions

Yan Liu

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Abstract

Objective:To study the expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions.Methods:50 cases of cervical squamous carcinoma,28 cases of cervical intraepithelial neoplasia(CIN) and 12 cases of normal cervical tissues ample were stained for ILK,PTEN by immunohistochemistry method.Results:ILK positive expression rate in cervical squamous carcinoma was significantly higher than that in normal cervical tissue and CIN I.The positive expression rate of PTEN in normal cervical tissue was 100.0%,but it was remarkably decreased in cervical squa mous carcinoma.Our analysis indicated that no significant relationship was found between the state of PTEN expression and invasion,metastasis and the clinical stage of the tumor.Conclusion:The higher expression of ILK and the lower expression of PTEN in cervical squamous carcinoma may play an important role in angiogenesis of cervical squamous carcinoma.

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What this paper is about

Objective:To study the expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions.Methods:50 cases of cervical squamous carcinoma,28 cases of cervical intraepithelial neoplasia(CIN) and 12 cases of normal cervical tissues ample were stained for ILK,PTEN by immunohistochemistry method.Results:ILK positive expression rate in cervical squamous carcinoma was significantly higher than that in normal cervical tissue and CIN I.The positive expression rate of PTEN in normal cervical tissue was 100.0%,but it was remarkably decreased in cervical squa mous carcinoma.Our analysis indicated that no significant relationship was found between the state of PTEN expression and invasion,metastasis and the clinical stage of the tumor.Conclusion:The higher expression of ILK and the lower expression of PTEN in cervical squamous carcinoma may play an important role in angiogenesis of cervical squamous carcinoma.

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Available abstract

Objective:To study the expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions.Methods:50 cases of cervical squamous carcinoma,28 cases of cervical intraepithelial neoplasia(CIN) and 12 cases of normal cervical tissues ample were stained for ILK,PTEN by immunohistochemistry method.Results:ILK positive expression rate in cervical squamous carcinoma was significantly higher than that in normal cervical tissue and CIN I.The positive expression rate of PTEN in normal cervical tissue was 100.0%,but it was remarkably decreased in cervical squa mous carcinoma.Our analysis indicated that no significant relationship was found between the state of PTEN expression and invasion,metastasis and the clinical stage of the tumor.Conclusion:The higher expression of ILK and the lower expression of PTEN in cervical squamous carcinoma may play an important role in angiogenesis of cervical squamous carcinoma.

Key concepts: PTEN, Medicine, Immunohistochemistry, Cervical carcinoma, Cervical intraepithelial neoplasia, Squamous carcinoma, Pathology, Cervical cancer

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The expression of ILK,PTEN in cervical squamous carcinoma and cervical precancerous lesions — Research Paper | ScholarLens