Clinicopathological significance and expression of E_2F-1,c-myc and p14~(ARF) protein in squamous cell carcinoma and adenocarcinoma of lung

OBJECTIVE: To investigate the expressions and clinicopathological characteristics of E2F-1,c-myc and p14ARF protein in the squamous carcinoma and adenocarcinoma of lung.METHODS:The expressions of E2F-1,c-myc and p14ARF protein of 71 cases of squamous cell carcinoma and adenocarcinoma of lung,and the related peritumoral lung tissues were detected by using immunohistochemical technique.RESULTS:The positive rates of E2F-1 and c-myc protein expression were 83.1%(59/71) and 81.7%(58/71) in cancerous tissues,which were significantly higher than 8.5%(6/71) in peritumoral lung tissues(P0.05).And the positive expression of p14ARF protein in cancerous tissues(52.1%) was lower than which in the peritumoral tissues(74.6%,P0.05).The expression rates of E2F-1,c-myc and p14ARF protein were no correlated with age,gender,tumor size,histological type,differentiation degree,lymphnode metastasis and TNM stage of patients(P0.05).And there were significant correlation in any two of three indicators of E2F-1,c-myc and p14ARF protein expressions by correlation analysis(P0.05).CONCLUSION: Abnormal expression of E2F-1,c-myc and p14ARF protein may play an important role in the tumorigenesis and progression for the squamous cell carcinoma and adenocarcinoma of lung.