Expression and Clinical Significance of GSTP1 Protein in Lung Cancer

Objective To study the clinicopathological significance of the expression of GSTP1 protein in lung cancer.Methods The expression of GSTP1 protein was detected by immunohistochemistry in 50 cases of primary lung adenocarcinoma specimens,20 adjacent noncancerous lung tissues,11 metastatic pulmonary adenocarcinoma and 14 squamous cell carcinoma tissues.Western blot was used to examine the GSTP1 protein level in 8 cases of lung adenocarcinoma,squamous cell carcinoma and adjuvant non-cancerous tissues.The relationship between the protein expression and clinicopathological features was analyzed.Results Overexpression of GSTP1 protein was shown in 32 and 9 cases of lung adenocarcinoma and squamous cell carcinoma tissues,respectively,which were much higher than that in adjuvant noncancerous lung tissues(χ2=6.655,P =0.010;χ2=3.927,P =0.048),but there was no statistically significant difference of GSTP1 expression between primary lung adenocarcinoma,metastatic pulmonary adenocarcinoma and squamous cell carcinoma tissues(P 0.05).The expression of GSTP1 protein was not correlated with age,sex,tumor size,differentiation or lymph node metastasis(P 0.05),but had a negative association with the prognosis of the lung adenocarcinoma patients(χ2=4.171,P =0.041).The expression of GSTP1 protein was higher in lung adenocarcinoma and squamous cell carcinoma tissues than that in non-cancerous lung tissues detected by Western blot(t =2.545,P = 0.023;t =2.337,P =0.035).Conclusion GSTP1 is up-regulated in lung cancer and positively correlated with the prognosis of the lung adenocarcinoma patients.