Clinicopathological significance and expression of E2F-1 protein in squamous cell carcinoma and adenocarcinoma of lung

Objective:To investigate the expressions and clinicopathological characteristics of E2F-1 protein in the squamous carcinoma and adenocarcinoma of lung.Methods: The expressions of E2F-1 protein of 71 cases of squamous cell carcinoma and adenocarcinoma of lung and the related peritumoral lung tissues were detected by using immunohistochemical technique.Results:: The positive rates of E2F-1 protein expression were 83.1%(59/71) in cancerous tissue,which was significantly higher than 8.5%(6/71) in peritumoral lung tissues(P0.05).Although E2F-1 protein expression rates were higher in adenocarcinoma than squamous cell carcinoma and negative correlation with differentiation degree,they were no significance difference in histological type and differentiation degree.And the expression rates of E2F-1 protein were no correlation with age,gender,tumor size,lymphnode metastasis and TNM stage of patients(P0.05).Conclusion: Abnormal expression of E2F-1 protein may play an important role in the tumorigenesis and progression for the squamous cell carcinoma and adenocarcinoma of lung.