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2009•Heilongjiang yiyao kexueRequires access

Significance of expression of K-ras and c-myc in lung carcinoma

Jia Ju-wen

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Abstract

Objective:To investigate the relationship between the expression of Kras,c-myc and their role in the occurrence and development of lung carcinoma.Methods:The expression of K-ras and c-myc was detected by immunohistochemistry in 53 patients with pulmonary carcinoma and 19 cases of normal lung tissue(NLT ).Results:There was an extensive expression of K-ras and c-myc in tumor cells(TC);Difference was not found in groups of pathological types(P0.01) and tumor size(P0.05).The expression of K-ras and c-myc in TC was both correlated with differentiated degree of lung cancer(P0.05);In lung carcinoma with lymph node metastasis,there was a significant difference(P0.05).Conclusion:K-ras and c-myc participate in the occurrence and development of lung carcinoma.

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What this paper is about

Objective:To investigate the relationship between the expression of Kras,c-myc and their role in the occurrence and development of lung carcinoma.Methods:The expression of K-ras and c-myc was detected by immunohistochemistry in 53 patients with pulmonary carcinoma and 19 cases of normal lung tissue(NLT ).Results:There was an extensive expression of K-ras and c-myc in tumor cells(TC);Difference was not found in groups of pathological types(P0.01) and tumor size(P0.05).The expression of K-ras and c-myc in TC was both correlated with differentiated degree of lung cancer(P0.05);In lung carcinoma with lymph node metastasis,there was a significant difference(P0.05).Conclusion:K-ras and c-myc participate in the occurrence and development of lung carcinoma.

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Available abstract

Objective:To investigate the relationship between the expression of Kras,c-myc and their role in the occurrence and development of lung carcinoma.Methods:The expression of K-ras and c-myc was detected by immunohistochemistry in 53 patients with pulmonary carcinoma and 19 cases of normal lung tissue(NLT ).Results:There was an extensive expression of K-ras and c-myc in tumor cells(TC);Difference was not found in groups of pathological types(P0.01) and tumor size(P0.05).The expression of K-ras and c-myc in TC was both correlated with differentiated degree of lung cancer(P0.05);In lung carcinoma with lymph node metastasis,there was a significant difference(P0.05).Conclusion:K-ras and c-myc participate in the occurrence and development of lung carcinoma.

Key concepts: Lung, Lung cancer, Immunohistochemistry, Carcinoma, Pathological, KRAS, Lymph node metastasis, Medicine

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