Significance of detection of anti-SmD1 antibody in systemic lupus erythematosus

Objective To investigate the significance of anti-SmD1 antibody and other auto-antibod- ies in systemic lupus erythematosus(SLE).Methods Forty-four SLE patients and 136 other rheumatic dis- eases patients were studied.The later group included Sj(?)gren's syndrome,undifferentiated connective tissue disease,ankylosing spondylitis,and rheumatoid arthritis.Immunoblotting was used to measure,the anti-SmD1 antibody,ANuA and anti-SSA60 000 antibody.ANA and anti-dsDNA were detected by indirect immunofluo- rescence,immunodotting was used to measure the anti-Sin antibody.Results The seropositive rate of anti- StuD1 was 47.7% in SLE patients.It was much higher than that of anti-Sm(P0.05).The specificity of anti- SmD1 was 97.1%.Conclusion The specificity of anti-StuD1 antibody is very high.Anti-SmD1 antibody's sensitivity was higher than that of anti-Sm antibody's.Combination of the five antibodies can significantly im- prove the sensitivity of these autoantibodies in the diagnosis of SLE.