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2010•Medical Journal of General Equipment HeadquartersRequires access

Fingerprinting of Kaglibao oral liquid by HPLC

Guo Dong-hua

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Abstract

Objective To establish a method of fingerprint chromatography to determine the content of Kaglibao oral liquid.Methods HPLC with Shim-pack VP-ODS(4.6×150 mm,5μm)column was used.Mobile phase consisted of methanol,acetonitrile,tetrahydrofuran and 0.1 mol/L sodium acetate buffer(8∶8∶7∶77,pH adjusted to 4.0 with acetic acid glacial).Flow rate was 1.0 ml.min-1.Detection wavelength was 334 nm.Results 13 peaks constituted the HPLC fingerprint of Kaglibao oral liquid.Conclusion The method is simple and accurate with a good reproducibility and can be used as a quality control for Kaglibao oral liquid.

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What this paper is about

Objective To establish a method of fingerprint chromatography to determine the content of Kaglibao oral liquid.Methods HPLC with Shim-pack VP-ODS(4.6×150 mm,5μm)column was used.Mobile phase consisted of methanol,acetonitrile,tetrahydrofuran and 0.1 mol/L sodium acetate buffer(8∶8∶7∶77,pH adjusted to 4.0 with acetic acid glacial).Flow rate was 1.0 ml.min-1.Detection wavelength was 334 nm.Results 13 peaks constituted the HPLC fingerprint of Kaglibao oral liquid.Conclusion The method is simple and accurate with a good reproducibility and can be used as a quality control for Kaglibao oral liquid.

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Available abstract

Objective To establish a method of fingerprint chromatography to determine the content of Kaglibao oral liquid.Methods HPLC with Shim-pack VP-ODS(4.6×150 mm,5μm)column was used.Mobile phase consisted of methanol,acetonitrile,tetrahydrofuran and 0.1 mol/L sodium acetate buffer(8∶8∶7∶77,pH adjusted to 4.0 with acetic acid glacial).Flow rate was 1.0 ml.min-1.Detection wavelength was 334 nm.Results 13 peaks constituted the HPLC fingerprint of Kaglibao oral liquid.Conclusion The method is simple and accurate with a good reproducibility and can be used as a quality control for Kaglibao oral liquid.

Key concepts: Chromatography, High-performance liquid chromatography, Acetic acid, Chemistry, Reproducibility, Sodium acetate, Acetonitrile, Tetrahydrofuran

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