The relationship of response of IGF-1,IL-1β and bone mineral density in type 2 diabetes mellitus

Objective To investigate the relationship of Insulin-like Growth Factor-1,Interleukin-1β level and bone mineral density in type 2 diabetes mellitus.Subjective and Methods We have chosen type 2 diabetes mellitus to determine the bone density,and selected 20 example bone quantity normal group,20 example bone quantity reduction group,20 example osteoporosis group according to the bone density,in addition selected 20 cases of health adults subjects with matched age and body mass index were regarded as normal control group.HbA_1c,IGF-1 and IL-1β were measured.Results(1)The IL-1β level in the T2DM osteoporosis group were higher than the level in the T2DM bone quantity normal group and normol control group(P0.005)(2) The IGF-1 level in the T2DM bone quantity reduction group and the T2DM osteoporosis group were lower than the level in the T2DM bone quantity normal group and normol control group(P0.005).Conclusion Insulin-like Growth Factor-1 and Interleukin-1β may influence the varying degree of BMD in type 2 diabetes.