2006•Chinese Journal of OsteoporosisRequires access

Relationship between bone mineral density and serum insulin-like growth factor-I in elder women with type 2 diabetes mellitus

HE Xuefeng

Abstract

Objective To investigate the relationship between bone mineral density(BMD) and the level of serum insulin-like growth factor-Ⅰ(IGF-Ⅰ) in elder women with type 2 diabetes mellitus.Methods BMD was measured by double-X ray bone mineral density meter.The level of serum IGF-Ⅰ was detected by enzyme-linked immunosorbant assay.Results Compared with normal control group,the incidence of osteoporosis(OP) in type 2 diabetic women was significantly higher (P0.05),and the level of serum IGF-Ⅰ was significantly lower (P0.05).In osteoporosis group with type 2 diabetes mellitus,the level of serum IGF-Ⅰ was significantly lower (P0.05),than those without osteoporosis.In type 2 diabetes mellitus group,the BMD was positively related with IGF-Ⅰ (P0.05).Conclusions The morbidity of osteoporosis in type 2 diabetes mellitus was higher.IGF-Ⅰ plays a critical role in the pathogenesis of bone formation.

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Key concepts: Medicine, Internal medicine, Bone mineral, Osteoporosis, Endocrinology, Diabetes mellitus, Type 2 Diabetes Mellitus, Incidence (geometry)