Study on Anti-oxidation Effect of Probucol in Rat With Adriamycin Induced Nephropathy

Objective:To observe the anti-oxidation effect of Probucol in rat with adriamycin induced nephropathy,and explore its protective mechanims.Methods:Forty male SD rats were randomly divided into 4 groups:normal group(group A),model group(group B),normal dose treatment group(group C) and high dose treatment group(group D).The models of adriamycin-induced nephropathy were established by injection of 6mg/kg adriamycin into the tail vein.After one week,medical interventions were initiated and lasted for 4 weeks.Level of 24h urinary protein was measured,contents of SOD and MDA were measured,and renal pathologic changes were examined.Results:Compared with that of model group,24 h urinary protein was significantly decreased in group C and group D(P0.05).The SOD activity was significantly increased and MDA was significantly decreased in group C and group D(P0.05),renal pathologic changes were improved.Conclusions:Probucol has an protective effect which can improve SOD activity,decrease MDA content,decrease the urinary protein and improve the renal pathologic changes.