Effect of Probucol on cystatin C,renal function and renal pathology in experiment rat

Objective To investigate the effects of Probucol on cystatin C(Cys C),renal function and renal pathology in rats with adriamycin-induced nephropathy,and explore the diagnostic value of Cys C in glomcrulus nephropathy.Methods Forty male SD rats were used.The rats were randomly divided into three groups:normal group,model group and treated group.The models of adriamycin-induced nephropathy were established by injection of 6mg/kg adriamycin into the tail vein.After 1 week,medicine interventions were used for 4 weeks.The level of 24-hour urinary protein and blood biochemistry indexs were measured,and renal pathologic changes were examined.Results In the treated group,24-hour urinary protein,Cys C levels were significantly decreased(P0.05),renal function was significantly improved,renal index was significantly improved.The SOD activity were significantly increased and the MDA were significantly decreased(P0.05),renal pathologic changes were improved.Conclusions In rats with adriamycin-induced nephropathy,Probucol can decrease the urinary protein and Cys C,improve the renal pathologic changes.It has protective effects.Serum Cys C may be good biomarkers for early diagnosis of glomcrulus nephropathy and they can reflect the change of renal function after contrast injection earlier than serum creatinine.