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2009•Jiangsu Medical JournalRequires access

Relationship between expressions of α2-HS-glycoprotein gene mRNA and protein in placenta and insulin resistance in preeclampsia patients

Xiaomei Liu

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Abstract

Objective To study the relationship between expressions of α2-HS-glycoprotein gene(AHSG) mRNA and AHSG protein in placenta and insulin resistance in preeclampsia patients. Methods Fasting maternal serum and umbilical cord blood AHSG,insulin and blood glucose(Glu) levels were detected in 36 cases of normal pregnancy woman(group A),24 cases of mild preeclampsia (group B) and 17 cases of severe preeclampsia (group C).The expressions of AHSG mRNA and AHSG protein in placenta were detected by semi-quantitative RT-PCR and Western blotting. ResultsThe levels of AHSG in mbilical cord serum were significantly higher in group B and C than those in group A(P0.01).The levels of umbilical cord serum Glu and insulin were significanlty lower in group C than those in group A(P0.05).Expression of AHSG mRNA in placenta of group C (1.32±0.38) was significantly higher than that in group A (0.57±0.17)or group B(0.64±0.14) (P0.05). Expression of AHSG protein in placenta of group C(0.58±10) was significantly higher than that in group A(0.28±0.11) or group B(0.30±0.10)(P0.05).Conclusion The level of AHSG in umbilical cord blood is significantly higher in preeclampsia neonate. Overxpression of AHSG mRNA in placenta of severe preeclampsia patients may induce insulin resistance,which may play an important role in the pathogenesis and development of preeclampsia.

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Objective To study the relationship between expressions of α2-HS-glycoprotein gene(AHSG) mRNA and AHSG protein in placenta and insulin resistance in preeclampsia patients. Methods Fasting maternal serum and umbilical cord blood AHSG,insulin and blood glucose(Glu) levels were detected in 36 cases of normal pregnancy woman(group A),24 cases of mild preeclampsia (group B) and 17 cases of severe preeclampsia (group C).The expressions of AHSG mRNA and AHSG protein in placenta were detected by semi-quantitative RT-PCR and Western blotting. ResultsThe levels of AHSG in mbilical cord serum were significantly higher in group B and C than those in group A(P0.01).The levels of umbilical cord serum Glu and insulin were significanlty lower in group C than those in group A(P0.05).Expression of AHSG mRNA in placenta of group C (1.32±0.38) was significantly higher than that in group A (0.57±0.17)or group B(0.64±0.14) (P0.05). Expression of AHSG protein in placenta of group C(0.58±10) was significantly higher than that in group A(0.28±0.11) or group B(0.30±0.10)(P0.05).Conclusion The level of AHSG in umbilical cord blood is significantly higher in preeclampsia neonate. Overxpression of AHSG mRNA in placenta of severe preeclampsia patients may induce insulin resistance,which may play an important role in the pathogenesis and development of preeclampsia.

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Available abstract

Objective To study the relationship between expressions of α2-HS-glycoprotein gene(AHSG) mRNA and AHSG protein in placenta and insulin resistance in preeclampsia patients. Methods Fasting maternal serum and umbilical cord blood AHSG,insulin and blood glucose(Glu) levels were detected in 36 cases of normal pregnancy woman(group A),24 cases of mild preeclampsia (group B) and 17 cases of severe preeclampsia (group C).The expressions of AHSG mRNA and AHSG protein in placenta were detected by semi-quantitative RT-PCR and Western blotting. ResultsThe levels of AHSG in mbilical cord serum were significantly higher in group B and C than those in group A(P0.01).The levels of umbilical cord serum Glu and insulin were significanlty lower in group C than those in group A(P0.05).Expression of AHSG mRNA in placenta of group C (1.32±0.38) was significantly higher than that in group A (0.57±0.17)or group B(0.64±0.14) (P0.05). Expression of AHSG protein in placenta of group C(0.58±10) was significantly higher than that in group A(0.28±0.11) or group B(0.30±0.10)(P0.05).Conclusion The level of AHSG in umbilical cord blood is significantly higher in preeclampsia neonate. Overxpression of AHSG mRNA in placenta of severe preeclampsia patients may induce insulin resistance,which may play an important role in the pathogenesis and development of preeclampsia.

Key concepts: Preeclampsia, Placenta, Internal medicine, Insulin resistance, Umbilical cord, Endocrinology, Group A, Medicine

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Relationship between expressions of α2-HS-glycoprotein gene mRNA and protein in placenta and insulin resistance in preeclampsia patients — Research Paper | ScholarLens