Expressions of Lipoxin A4 Receptor,5-Lipoxygenase and Interleukin-1β in Placenta of Preeclampsia and Their Clinical Significance

Objective To investigate the mRNA expressions of lipoxin A4 receptor( ALX-R),5-lipoxygenase( 5-LOX) and interleukin-1β( IL-1β) in placenta tissues of patients with preeclampsia,and to explore the clinical significance of the mRNA expressions. Methods RT-PCR was used to detect mRNA expressions of ALX-R,5-LOX,IL-1β in placenta tissues of 30 patients with preeclampsia( including 20 cases of severe preeclampsia and 10 cases of mild preeclampsia) and 20 normal pregnant women( control group). Results ① Compared with mild preeclampsia group and control group,the mRNA expression of ALX-R was lower in severe preeclampsia group while the mRNA expressions of 5-LOX and IL-1β were higher( P 0. 05); There was no significant difference in the mRNA expressions of ALX-R,5-LOX and IL-1β between mild preeclampsia group and control group( P 0. 05). ②The expression levels of ALX-R mRNA negatively correlated with the expression levels of IL-1β mRNA,5-LOX mRNA in severe preeclampsia group and control group( P 0. 05). The expression of 5-LOX mRNA positively correlated with the expression of IL-1β mRNA in severe preeclampsia group as well as in mild preeclampsia group and control group( P 0. 05).Conclusion The expression of ALX-R decreases while the expressions of 5-LOX and IL-1β increase in placenta tissues of preeclampsia,which suggests that ALX-R,5-LOX and IL-1β may play an important role in the development of preeclampsia.