Curative effect and safety of intensive statin therapy in treatment of acute coronary syndrome after percutaneous coronary intervention

Objective To observe the curative effect and safety of intensive statin therapy in treatment of acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI).Methods The ACS patients(n=239) with PCI were chosen from Jan.2010 to Jun.2011,and then randomly divided into routine group(n=119) and intensive group(n=120) after collecting fast blood samples in the morning of the next day after hospitalization.The routine group was given atorvastatin(20 mg/qN) and intensive group was orally given atorvastatin(80 mg) immediately after blood samples collecting and then given atorvastatin(40 mg/qN) for maintenance treatment.The changes of blood fat(TC and LDL-C),ALT,Cr,hs-CRP and platelet aggregation induced by ADP were compared between two groups before treatment and 7 days and one month after treatment.Results The levels of TC and LDL-C decreased in two groups after treatment and decreased as treatment time expansion,which was more significant in intensive group(P0.05).There was no statistical difference in ALT,Cr,platelet aggregation and clopidogrel resistance between two groups(P0.05).The recurrence rate of angina and incidence of heart failure were lower in intensive group than those in routine group(angina: 26.9%vs.15%;heart failure: 18.5%vs.9.2%,P0.05).There was no statistical difference in relapse myocardial infarction and cardiac death between two groups(P0.05).Conclusion Early taking high-dose atorvastatin can reduce the level of blood fat and incidence of major adverse cardiac events,and has no influence on antiplatelet drugs in ACS patients with PCI.