Influence of atorvastatin on effect and inflammatory factors after percutaneous transluminal coronary intervention in patients with acute coronary syndrome

Objective To investigate the influence of two routine doses of atorvastatin on effect and inflammatory factors after percutaneous coronary intervention( PCI) in patients with acute coronary syndrome( ACS). Methods A total of 102 ACS patients underwent PCI surgeries were randomly divided into group A( 10 mg of atorvastatin calcium) and group B( 20 mg of atorvastatin calcium). Serum lipid[total cholesterol( TC),low density lipoprotein cholesterol( LDL-C),triglyceride( TG) ]and inflammatory cytokines[high sensitivity C-reactive protein( hs-CRP),tumor necrosis factor( TNF-α),interleukin-6( IL-6) ]levels were compared between two groups,and incidence of major adverse cardiac events were observed on the 30 th and 180 th day after operation. Results After PCI,there were significant differences in TC,LDL-C and TG when compared with preoperative period in both of the group A and the group B( P 0. 05). There were no significant differences in TNF-α,IL-6 and hs-CRP at the time points of before treatment and 24 hours after treatment in both groups( P 0. 05),but there were significant differences at the time points of the 7th day and 30 th day after operation between two groups( P 0. 05). There was no significant difference of incidence rate of major adverse cardiac events between two groups( P 0. 05). Conclusion Two doses of atorvastatin are safe and effective in the treatment of ACS patients with PCI,and it can significantly decrease the levels of inflammatory factors after PCI operation.