Effect of high dose statin pretreatment for percutaneous coronary intervention patients with acute coronary syndrome

【Objective】 To investigate the influence of high dose statin pretreatment on serum C-reactive protein(CRP) and lipid levels for percutaneous coronary intervention(PCI) patients with acute coronary syndrome(ACS).【Methods】 150 patients with ACS who were admitted to suffering from PCI from May 2010 to October 2011 were randomly divided into intensive therapy group and the conventional therapy group with 75 cases in each group.Patients in the intensive therapy group were given atorvastatin 80 mg orally,qd;but patients in the conventional therapy group received atorvastatin 20 mg orally,qd.A 7-day pretreatment with atorvastatin was given to the subjects.The two groups were identical in other medication treatment.CRP and lipid levels were measured at baseline,1 and 7 day after the procedure.【Results】 At baseline,1 and 7 day after PCI,CRP levels were respectively(8.1±3.1),(12.6±3.2),(7.9±2.7) mg/L in the intensive therapy group,and(8.21±3.0),(13.0±3.3),(11.8 ± 3.1) mg/L in the conventional therapy group.Postoperative CRP levels were first increased and then decreased,with no significant difference at 1 day after treatment(P 0.05) and significant differences at 7 day after treatment(P 0.05).Before treatment,TC,TG,HDL and LDL levels were not significantly different.After treatment,TC,TG and LDL levels were decreased,but HDL were increased,and the intensive therapy group compared with the conventional treatment group were significantly different(P 0.05).【Conclusion】 High-dose short-term intensive statin pretreatment for acute coronary syndrome underwent PCI can not only strengthen decreasing the lipid,but also can significantly reduce inflammation of PCI,thereby reducing the incidence of postoperative cardiovascular events.