Effect of proanthocyanidins sustained-release tablet on the anti-stress function of radiation-injured mice

Objective:To observe the effect of proanthocyanidins sustained-release tablet on the anti-stress function of radiation-injured mice.Methods:One hundred and fifty healthy male ICR mice were selected and randomly divided into control group,model group,ginsenosides group,proanthocyanidins sustained-release tablet of low and high dosage groups(100 mg·kg-1,500 mg·kg-1).The mice were given 0.9% NaCl solution and different drugs by intragastric administration for 14 days.At the 7th day,except the control group,the other groups were injured by 60Co γ irradiation once.The effect of proanthocyanidins sustained-release tablet on anti-stress function of radiation-injured mice was investigated by the antifatigue and hypoxia-resistant tests.Results:The proanthocyanidins sustained-release tablet of low and high dosage groups could significantly extend loaded swimming duration and hypoxia-resistant time of radiation-injured mice.Compared with model group,the difference was significant in low dosage group(P 0.05),there was highly significant difference between high dosage group and positive control group(P 0.01).The hypoxiaresistant time was significantly longer in high dosage group than in model group(P 0.01),but there was no significant difference between low dosage group and model group(P 0.05).Proanthocyanidins sustained-release tablet of low,high dosage groups and positive control group could significantly inhibit synthesis of MDA induced by acute hypoxia and re-exposure treatment,and there was significant difference between low dosage group and model group(P 0.05),and highly significant difference between high dosage group and model group(P 0.01).Conclusion:Proanthocyanidins sustained-release tablet can significantly strengthen the power of resistance and the anti-stress function of radiation-injured mice.