Expression and clinical significance of CD147 and MMP-3 in cervical carcinoma

Objective:To detect the expression of CD147 and matrix metalloproteinase-3 (MMP-3) in cervical carcinoma tissues and further to explore the correlation between their expression and the invasion and metastasis of cervical carcinoma.Methods:The expression of CD147 and MMP-3 were examined with inmunohistochemical technique (S-P) in the specmiens gathered from 50 cases of cervical carcinoma and 30 cases of cervical intraepithelial neoplasia (CIN) and 10 cases of cervical epithelium.Results:The positive expression percentage of CD147 was 82.0% in cervical carcinoma tissues,which was higher in cervical carcinoma than that in the cervical epithelium tissues (40.0%,P0.01).The percentage of positive expression MMP-3 was 86.0% in cervical cancer and was 83.3% in CIN,which were higher in cervical epithelium tissues (20.0%,P0.05～0.01).The expression of CD147 and MMP-3 were correlated with the differentiation of tumor cells and lymph node metastasis (P0.05),but not with the age,the nationality and tumour size (P0.05).The expression of CD147 was positively correlated with the expression of MMP-3 in cervical carcinoma (r=0.441,P0.01).Conclusion:The expression of CD147 was positively related to that of MMP-3,CD147 and MMP-3 could be potential indexes of envaluating invasion and metastasis of cervical carcinoma.