Long Term Toxicity Test for Shenguangyuan Granule

To investigate whether long term administration of Shenguangyuan granule to rats has toxicity. The Wistar rats were divided into three groups, and the dosage of 3.6g/kg, 7.2g/kg, and 14.48g/kg were perfused respectively to the three groups for 6 months. These dosages were 20,40 and 80 times more than the clinical dosages respectively. 6 months later after discontinuation, all the body weights, hematological or biochemical indexes, both relative weight and morphologies of heart, liver, spleen, lung, kidney, brain, testis and uterus were tested.No evident abnormal change of every index was observed in every group.[Conclusion]Long term administration of Shenguangyuan granule to rats was safe.