Association of T174M Allele Polymorphism of Angiotensinogen Gene and Essential Hypertension in Kazakans of Xinjiang

To investigate the relationship between the T174M allele polymorphism of angiotensinogen (AGT) gene and the essential hypertension in Kazakans of Xinjiang, Polymerase chain reaction and restriction fragment length polymorphism (PCRRFEP) methods were used to detect the T174M polymorphism of AGT gene in Kazakans including 128 patients and 74 normotensive control. The genotype frequencies of T174M were TT 78.91%; TM 20.31%, MM 0.78% respectively; T174 and M174 allele frequencies were 89.06%, 10.94% respectively in hypertension group. While the corresponding frequencies were 78.38%, 21.62%, 0%; 89.19%, 10.81% respectively in control group. There are no significant difference in MM174 genotype and M174 allele frequencies of angiotensinogen between hypertension and control groups(P0.05). In addition, T174 and M174 allele frequencies had also no statistic significance in the subgroups classified according to sex(P0.05). It is concluded that the M174 variant of the angiotensinogen may not play a critical role in the pathogenesis of hypertension in Kazakans of Xinjiang.