e0023 The study for relationship between the angiotensin II type 1 receptor gene polymorphism and essential hypertension in kazakans of Xinjiang

Objective To investigate the relationship between the A1166C allele polymorphism of angiotensin II Type 1 Receptor (AT1R) gene and the essential hypertension in Kazakans of Xinjiang. Methods PCR and restriction fragment length polymorphism methods (PCR-RFLP) were used to detect the A1166C polymorphism of AT1R gene in Kazakans including 321 patients with hypertension and 203 normotensive controls. The frequencies of genotype distribution hypertensives and normotensives were studied. Results The genotype frequencies of A1166C were AA 0.7664, AC 0.2274, CC 0.0062 in the hypertension group and the corresponding frequencies were 0.7537, 0.2463, 0 in the control group respectively; The A1166 and 1166C allele frequencies were 0.8801, 0.1199 respectively in hypertension group and 0.8768, 0.1232 in normotensive group; The distribution of A1166C-genotype and the allele frequencies of A1166/1166C were not statistically significant in hypertension group as compared to normotensive group (p>0.05). Conclusion There was no significant association found between the A1166C polymorphism of AT1R gene and essential hypertension in Kazakans of Xinjiang. Abbreviations: Angiotensin II Type 1 Receptor (AT1R).