The Relationship between Essential Hypertensive and Polymorphism of AT_1R Gene A1166C in Kazakans of Xinjiang

To investigate the relationship between Essential Hypertensive and polymorphism of angiotensinⅡtypeⅠreceptor(AT1R) gene A1166C in Kazakans of Xinjiang.Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) methods were used to detect the A1166C polymorphism of AT1R gene in Kazakans including 200 patients with hypertension and 220 normotensive controls.The genotype frequencies of AA、AC、CC and the A/C allele frequencies were not significant differences in hypertension group compared with normotensive group,meanwhile,the frequencies of men and women's C allele were not significant differences.Conclusions There was no significant association found between the A1166C polymorphism of AT1R gene and essential hypertension in Kazakans of Xinjiang.