Relationship between the Polymorphism of Angiotensinogen Gene M235T and Human Essential Hypertension in Kazakans of Xinjiang

To investigate the relationship between the M 235T allele polymorphism of angiotensinogen (AGT) gene and the essential hypertension in Kazakans of Xinjiang, polymerase Chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the M235T polymorphism of AGT gene in Kazakans including 132 patients and 75 normotensive controls. Results are that the genotype frequencies of M235T were TT 0,TM41.67%, MM 58.33% respectively; T235 and M235 allele frequencies were 20.83%, 79.17% respectively in hypertension group. While the corresponding frequencies were 78.38%,21.62%,0%;89.19%,10.81% respectively in control group. There was no significant difference in 235MM genotype and 235M allele frequencies of angiotensinogen between hypertension and control groups (P0.05). In addition, T235 and M235 allele frequencies had also no statistic significance in the usbgroups classified according to sex (P0.05). It is conclused there was no significant association found between the M235T allele polymorphism of AGT gene and essential hypertension in Kazakans of Xinjiang.