2011•Zhongguo sheng-hua yaowu zazhiRequires access

Treatment of Anluohuaxianwan on alcoholic fatty liver in rats

Xiumei Zhang

Abstract

Purpose To observe the effects of Anluohuaxianwan on alcohol-induced fatty liver in rats.Methods Rat fatty liver model was induced by continuous intragastric administration of alcohol for 6 weeks and then the animals received different doses of Anluohuaxianwan for 4 weeks.General conditions,serum ALT and AST activity;TC and TG level were observed;TG,MDA and SOD levels in liver homogenate and pathological changes in liver were also tested.Results Anluohuaxianwan can decrease the alcoholic fatty liver serum alanine aminotransferase(ALT),aspartate aminotransferase(AST) and total cholesterol(TC) level,decrease the hepatic triglyceride(TG) content,increased hepatic superoxide dismutase(SOD) activity,and decrease the liver tissue malondialdehyde(MDA) level.Pathological observation results show that Anluohuaxianwan can significantly improve the alcoholic fatty liver pathological liver tissue damage.Conclusion Anluohuaxianwan has therapeutic effect on alcoholic fatty liver.

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Key concepts: Alcoholic fatty liver, Fatty liver, Internal medicine, Malondialdehyde, Triglyceride, Pathological, Endocrinology, Steatosis