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2010•The Journal of Clinical PsychiatryRequires access

A comparative study of aripiprazole and quetiapine in the treatment of senile schizophrenia

Feng Fen

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Abstract

Objective:To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia. Method:86 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or quetiapine treatment respectively. The periods of treatment were 12 weeks. The positive and negative symptom scale ( PANSS) and treatment emergent symptom scale ( TESS) were used to evaluate the efficacy and side effects. Results:The two groups showed significant decreases on PANSS score after 12 week's treatment. The excellence rate and effective rate was 69. 76% and 88. 37% respectively in aripiprazole group,while 72. 09% and 90. 70% in the quetiapine group. No significant difference was found between the two groups ( P 0. 05) ,both groups had similar side effects. Conclusion:Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia.

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Objective:To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia. Method:86 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or quetiapine treatment respectively. The periods of treatment were 12 weeks. The positive and negative symptom scale ( PANSS) and treatment emergent symptom scale ( TESS) were used to evaluate the efficacy and side effects. Results:The two groups showed significant decreases on PANSS score after 12 week's treatment. The excellence rate and effective rate was 69. 76% and 88. 37% respectively in aripiprazole group,while 72. 09% and 90. 70% in the quetiapine group. No significant difference was found between the two groups ( P 0. 05) ,both groups had similar side effects. Conclusion:Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia.

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Available abstract

Objective:To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia. Method:86 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or quetiapine treatment respectively. The periods of treatment were 12 weeks. The positive and negative symptom scale ( PANSS) and treatment emergent symptom scale ( TESS) were used to evaluate the efficacy and side effects. Results:The two groups showed significant decreases on PANSS score after 12 week's treatment. The excellence rate and effective rate was 69. 76% and 88. 37% respectively in aripiprazole group,while 72. 09% and 90. 70% in the quetiapine group. No significant difference was found between the two groups ( P 0. 05) ,both groups had similar side effects. Conclusion:Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia.

Key concepts: Aripiprazole, Quetiapine, Schizophrenia (object-oriented programming), Negative symptom, Medicine, Psychiatry, Psychology, Significant difference

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