A clinical comparative study in first-onset schizophrenia patients treated with Aripiprazole and Quetiapine

Objective To study the clinical effects of Aripiprazole and Quetiapine in the treatment of first-onset schizophrenia.Methods 63 adult patients who were diagnosed as schizophreniain accordance with the CCMD-3 diagnosis standard were recruited in this study.All the cases were randomized into two groups and were treated with Aripiprazole and Quetiapine for 8 weeks.The positive and negative syndrome scale(PANSS) and treatment emergent side effect scale(TESS) were used to evaluate efficacy and adverse effects respectively.Results The significant efficacy rates of Aripiprazole was 93.55%,Quetiapine was 90.63%,there was no significant difference(P 0.05).Before and after treatment between Aripiprazole group and Quetiapine group,the PANSS score had no significant difference(P 0.05).The level of LEP and TG was elevated which were treated by Aripiprazole,the difference was statistically significant(P 0.05).The level of LEP,PRL,BG and TG was elevated which were treated by Quetiapine,the difference was statistically significant(P 0.05).Conclusion The curative effect of first-onset schizophrenia between Aripiprazole and Quetiapine is quite,but the adverse reactions are different,the former is better than the latter.