A Control Study of Aripiprazole and Quetiapine in Treatment of Senile Schizophrenic

Objective To compare the efficacy and safety between aripiprazole and quetiapine in the treatment of senile schizophrenia.Methods A total of 82 patients with senile schizophrenia were randomly divided into two groups receiving aripiprazole or quetiapine treatment.The periods of treatment in both groups were 8 weeks.The positive and negative symptom scale(PANSS) and treatment emergent symptom scale(TESS) were used to evaluate the efficacy and side effects,the quality of life was measured by World Health Organization quality of life questionnaire(WHOQOL-100).Results The significant efficacy rate of aripiprazole group was 70.7% and the efficacy rate was 90.2% after 8 weeks,while 73.2% and 92.7% in quetiapine group.There were no statistical difference between two groups(P0.05).Except item of psychic support,all item in WHOQOL-100 had a significant improvement in patients of aripiprazole group.Compared with quetiapine group,patients in aripiprazole group had marked improvement on those fields such as life,psychology,independence and social relationship.The incidence rate of adverse effect in aripiprazole group and that in quetiapine group,without statistical difference between them(P0.05).Conclusion Aripiprazole and quetiapine are effective and safe in the treatment of senile schizophrenia.The patients in aripiprazole group have a better quality of life than those in quetiapine group.