The Expression and Clinical Significance of Drug-resistance Genes GST-Л and LRP in Ovarian Carcinoma Tissue

Objective: To study the expression of glutation-S-transferaseЛ (GST-Л) and pulmonary drug-resistant protein (LRP) in ovarian epithelial malignant tumors, and the relationship to clinico-pathology. Methods: 30 cases of ovarian epithelial malignant tumors were included. The expression of GST-Л and LRP were analyzed by immunohistochemistry (S-P), and the relationship between the expression and pathological type, histology differentiation, chemotherapy effect, and prognosis were reviewed. Results: ①The positive expressive rate of GST-Л and LRP was 66.6%, 73.3%, accordingly. ② The positive expressive rate of LRP and GST-Л in stage Ⅲ and Ⅳ was 99% and 76.5%, respectively, which significantly higher than those in stage Ⅰand Ⅱ(46.2%, 16.7%, respectively). ③ The expression rate of LRP and GST-Л in G 3 was higher than in G 1 and G 2, but the difference was no apparent (P0.05). ④ There existed co-expression in LRP and GST-Л whose strong co-expression predicted poor chemotherapy effect and prognosis. Conclusions: Our study indicated that the LRP and GST-Л express constantly in epithelial ovarian carcinomas. The expression is relevant with the clinical stage. Detection of both of them can predict the shortly chemotherapy effect, and help choose the chemotherapy projects.