Research on the rend of drug resistance of the smear positive tuberculosis and tuberculosis control project

Objective To evaluate 1993—2000 Dalian tuberculosis prevention and treatment result and the trend of drug resistance of the smear positive tuberculosis.Methods Statistics the date to proceed the brigade row the analysis to epidemic situation.All of the strains of M .tuberculosis from new register smear positive tuberculosis were test for resistance to INH,RFP,EMB and SM by absolute concentration methods.Results In 1993—2000 DOTS persistence rate were 7.0%,27.0%,41.4%,35.1%,68.4%,73.8%,77.6%,89.6% respectively.The cure rate were 54.0%,67.1,73.2%,84.3%,91.1%,93.5%,94.0%,92.7% respectively.The rate of initial resistance was declined from 34.6% in 1993—1994 to 18.2% in 1999—2000.The rate of acquired resistance declined form 52.1% in 1993—1994 to 35.7% in 1999—2000.Conclusion The rate of initial and acquired resistance was declined.The main reason is due to the convergence case-management and the DOTS strategy.